Laser method can also be used for endothelial function assessment in clinical practice.

can be assessed. Although the endothelium mediators involved in the vasodilatation induced by acetylcholine iontophoresis have been discussed, the late vasodilatation induced by local heating is mainly due to endothelial NO release. The other elements that strengthen the use of LSCI as a clinical tool for endothelial assessment are: (i) its ease of use, enabling nurses to perform the measurement, (ii) its low cost, the expense of the iontophoresis chamber is about 10 euros per measurement, (iii) the ability to perform measurements when patient moves slightly and (iv) its safety because it is a non-invasive painless measurement. Therefore, the laser method, especially LSCI, appears to be a promising exciting tool to study endothelial function and dysfunction in clinical practice.